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KMID : 0385019980140020229
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Korean Journal of Laboratory Animal Science
1998 Volume.14 No. 2 p.229 ~ p.234
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A Study on Nematological Values During Normal Pregnancy in Sprague-Dawley Rats
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정문구/Chung, Moon Koo
송시환/김종춘/서정은/김영희/Song, Si Whan/Kim, Jong Choon/Suh, Jeong Eun/Kim, Young Hee
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Abstract
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The aim of our investigation was to compare the hematological values of pregnant and nonpregnant Sprague-Dawley (SD) rats. Hematological values in venous blood were measured with automated methodology in twelve pregnant and ten non-pregnant rats. The white blood cell count measured on gestational day (GD) 0, 3, 6, 9, 12, and 15 was higher than that of non-pregnant rats. According to the differential count, there were marked increases in the numbers of lymphocytes and neutrophils, which result in the increased white blood cell count in pregnant rats. The lymphocyte count of pregnant rats decreased progressively during pregnancy, whereas the neutrophil count increased progressively with advancing pregnancy. The platelet count measured on GD 15 and 21 was higher than the value of non-pregnant rats. On the contrary, the red blood cell count, hemoglobin concentration, and hematocrit measured on GD 6, 12, 18, and 21 were lower than the normal value. There were no differences in MCV, MCH, and MCHC between pregnant and non-pregnant rats. The white blood cell count, red blood cell count, hemoglobin concentration, and hematocrit of pregnant rats declined progressively during pregnancy. These data can be used not only as a comparative value for the effective evaluation of toxicity data obtained in the reproductive toxicology studies, but also as a contribution to biological characterization of SD rats.
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